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Question

Posted on: March 6 2013

What phosphate do we use to prepare the solution of Joulie NF V?

On the neonatology service of our hospital there is demand for jouliesolution (phosphoric acid Solution NF V). However, We cannot get sodium phosphate anywhere. Is it possible to prepare this solution with Na2HPO4 or NaH2PO4, and if so, how do we calculate the correct quantity?

Answer

In The American literature we find the following composition:
Sodium Phosphate Dibasic Heptahydrate crystals, USP 136g
Phosphoric Acid 34.7 ml
Preserved Water (with parabens) QSAD 1000 ml
Mixing Instructions:

  1. Dissolve crystals in a portion or heated water. (Water is heated because sometimes the parabens precipitate out during compounding)
  2. Add acid to increase solubility of crystals and mix well.
  3. Pour solution into a graduated cylinder and QS with water.
  4. Pour solution into a plastic jug, cap, seal, and label.
Beyond-Use Date: 180 days at room temperature.

This solution contains 1mMol of phosphate or 30.4 mg of phosphate per 1ml.

this confirms my suspicion that the sodium phosphate described in the NF V is the dinatrium phosphate. With us this occurs with 2 molecules of crystal water. I have my doubts whether the expression of the amount of phosphoric acid in the American compound in ML is correct. I suspect that & #039; ml & #039; should be replaced with & #039; G & #039;.