Aqua Conservans in nasal drops, can this be used?

P class = "P1" > span class = "S1" > Ciliotoxicity or methyl-and propyl-P-hydroxybenzoates: A dose-response and surface-response study. P class = "P2" > span class = "S2" > a href = "http://www.ncbi.nlm.nih.gov/pubmed/? term = Jian% 20L% 5BAuthor% 5D & cauthor = true & cauthor_uid = 7904636" > Jian L span class = "S3" > 1, a href = "http://www.ncbi.nlm.nih.gov/pubmed/? term = Li% 20Wan% 20Po% 20A% 5BAuthor% 5D & cauthor = true & cauthor_uid = 7904636" > span class = "S4" > Li Wan Po A . P class = "P3" > Abstract P class = "P7" > span class = "S1" > The effect of methyl-p-hydroxybenzoate (methyl paraben, MHB) and Propyl-P-hydroxybenzoate (propyl paraben, PHB) on Ciliary beat frequency was investigated using surface-response methodology. Both compounds are shown to be ciliotoxic at concentrations equal to or lower than those in use for Pres erving aqueous formulations. The dose-response curves show the typical sigmoidal pattern. Interaction by the two compounds is evidenced by the curved response surface for ciliotoxicity. P class = "P7" > span class = "S1" > You can best use isotone excipient for nasal drops a phosphate solution PH = 7  : NaH2PO4 0.22 G; Na2HPO4 0.36 G; NaCl 0.7 g; Benzalkonium chloride 0.01 g and water for injections up to 100 ml