To recipes helpdesk

Question

Posted on: October 28 2015

Can a stock solution be prepared with Urfamycine?

Prescription NKO-Doctor: 12 vials of Urfamycine 750mg each time dissolve in 5ml solvent for injection + 40 ml Pulmicort 0.5 mg/ml (20 amp) + 100ml physiological serum = 200 ml. Is This stock solution stable, can it be stored in the refrigerator?

Answer

P class = "P1" > span style = "line-height: 1.6 em;" >   span style = "FONT-family: TimesNewRomanPS; font-size: 11pt; font-weight: 700; line-height: 1.6 em;" > How to store Urfamycine div class = "page" title = "Page 3" > div class = "layoutArea" > div class = "column" >

span style = "FONT-size: 11.000000 pt; font-family: ' TimesNewRomanPSMT '" > store at room temperature (15-25 °C). The prepared solution is usable for several hours at room temperature.  

span style = "FONT-size: 11.000000 pt; font-family: ' TimesNewRomanPSMT '" > There is such a thing as the Q10 rule, which says that the stability of a product doubles for every ten degrees we reduce the temperature. The reverse works of course as well.

So suppose at room temperature (20 °C) 2 hours stable; at 10 degrees 4 hours and at-5 ° C +/-  10 hours.    

Pulmicort is a suspension and for this product is clearly indicated do not freeze. After all, a lowering of the temperature can   make changes to the particle size by lowering the dissolved fraction. Little is completely insoluble!!

I fear that the client will have to compose his solution for inhalation itself, taking into account the quantities and proportions prescribed by the physician.