Ciloxan & De-icol ear drops, solution crystallizes out after 2 nights of preservation in the Frigo.

The composition of the Icol is:     span style = "FONT-family: ArialMT; font-size: 10pt;" > dexamethasone sodium phosphate 1mg-chloramphenicol 4mg – for 1 ml   and     span style = "FONT-size: 10pt; font-family: ArialMT;" > Boric acid – Sodium tetraborate 10 H span style = "FONT-size: 6pt; font-family: ArialMT; vertical-align:-1pt;" > 2 span style = "FONT-size: 10pt; font-family: ArialMT;" > O-methylparahydroxybenzoate-purified water

span style = "FONT-family: ArialMT; font-size: 10pt;" > The composition of Ciloxan is:   span style = "FONT-family: TimesNewRomanPSMT; font-size: 11pt;" > 1 ml solution contains 3 mg ciprofloxacin (as hydrochloride); h SPAN style = "FONT-family: TimesNewRomanPSMT; font-size: 11pt; " > Ulpstof with known effect: 1 ml solution contains 0.06 mg Benzalkonium chloride.

fontface = "TimesNewRomanPS" > span style = "FONT-size: 14.6667 px;" > List of excipients  :   span style = "FONT-family: TimesNewRomanPSMT; font-size: 11pt;" > Benzalkonium chloride Dinatriumedetaat Mannitol Sodium acetate Acetic acid   span style = "FONT-family: TimesNewRomanPSMT; font-size: 11pt;" > hydrochloric acid and/or sodium hydroxide (for pH setting) purified water

span style = "FONT-family: TimesNewRomanPSMT; font-size: 11pt;" > When the various constituents are overtaken, there are various incompatibilities dexametasone phosphate, Benzalkonium +, ciprofloxacineH +, which lead to ion pairs, which Presumably depending on their molecular weight can be water insoluble and presumably crystallize when stored in refrigerator  

span style = "FONT-family: timesnewromanpsmt; font-size: 11pt;" > Therefore most likely incompatible because if the crystallization is accelerated in the fridge, it can occur in the longer term at room temperature.